Tablets - 25 mg

Solution for injection - 0.5 mg / 1 ml

Solution for injection - (40 mg + 0.02 ml)/2 ml

Solution for injection - 5 mg/ml - 20 ml

Solution for injection - 10 mg/2 ml

Rectal solution - 5 mg/2.5 ml

Tablets - 500 mg

Tablets - 500 mg

Tablets - 75 mg

Tablets - 500 mg

Tablets - 500 mg

Solution for injection - (0.5%) 5 mg/1 ml

Solution for injection - (96 mg + 104 mg)/1 ml (20%)

Caffeine is a substance that stimulates the CNS. It inhibits the enzyme phosphodiesterase and has an antagonistic effect at central adenosine receptors. In the CNS it acts primarily in the higher centers and gives a condition of wakefulness, increasing the rate and depth of respiration sometimes. Its stimulating action in vasomotor centers of medulla and the positive inotropic effect in the myocardium are compensated by the peripheral vasodilator effect in the arterioles, so it has little effect on blood pressure.

The diuretic action of caffeine is weaker than that of theophylline.

Caffeine can increase the absorption of ergotamine and sometimes is combined with the latter for the treatment of migraine. To increase the solubility of caffeine, it is combined with sodium benzoate and so is obtained caffeine sodium benzoate, which is used in the form of solution for injection.

Caffeine is well distributed in the body. It crosses the central nervous system and passes in saliva; in small concentrations it passes into breast milk.

This medicine is to be given only under the direct supervision of a doctor.

Kafeine natrium benzoat is indicated:

• as breathing and blood circulation analeptic, mainly in diseases with high temperature and infectious diseases, as well as during poisoning.

Solution for injection - (10%) 200 mg/2 ml

Solution for injection - 40 mg/2 ml

Solution for injection - (1000 mg + 0.5 mg)/50 ml

Solution for injection - (2%) 20 mg/ml

Film coated tablets - (251 mg + 61.2 mg + 2.54 mg)

Oral suspension - 160 mg / 5 ml

Syrup - 120 mg / 5 ml