Film coated tablets - 300 mg + 25 mg

Co-Ultesan is a combination of two active substances, irbesartan and hydrochlorothiazide.

Irbesartan belongs to a group of medicines known as angiotensin II receptors antagonists. Angiotensin II is a substance produced in the body which binds to receptors in blood vessels causing them to tighten. This results in an increase in blood pressure. Irbesartan prevents the binding of angiotensin II to these receptors, causing the blood vessels to relax and the blood pressure to lower.

Hydrochlorothiazide belongs to a group of medicines called thiazide diuretics, that causes increased urine output and so causes a lowering of blood pressure.

The two active ingredients in Co-Ultesan work together to lower blood pressure further than if either was given alone.

Co-Ultesan is used to treat high blood pressure, when treatment with irbesartan or hydrochlorothiazide alone did not provide adequate control of your blood pressure.

Tablets - 6.25 mg

Tablets - 100 mg

Tablets - 10 mg

Film coated tablets - 10 mg

Lecorin contains the active substance lercanidipine hydrochloride, that is a dihydropyridine calcium-channel blocker with actions similar to those of nifedipine.

Lecorin influences the myocardial cells, the cells within the specialised conducting system of the heart, and the cells of vascular smooth muscle. Thus, myocardial contractility, the formation and propagation of the electrical impulse and coronary or systemic vascular tone may be diminished.

Lecorin is indicated for the treatment of mild to moderate essential hypertension.

Film coated tablets - (10 mg + 20 mg)

Film coated tablets - 5 mg

Losartan is an angiotensin II receptor antagonist. Angiotensin II is a chemical in your blood that tightens your blood vessels. Losartan blocks this effect causing the blood vessels to relax and so lowers your blood pressure.

Losartan is indicated:

• for the treatment of hypertension;
• for the treatment of heart failure in combination with diuretics and/or digitalis medicine;
• for the prevention of stroke in hypertensive patients with left ventricular hypertrophy;
• in the treatment of renal disease in hypertensive, type 2 diabetic patients with proteinuria, as part of their antihypertensive treatment. 

Film coated tablets - 20 mg

Film coated tablets - 50 mg

Metoprolol belongs to a group of drugs called cardioselective beta-blockers. It reduces cardiac contraction and decreases the heart rate.

Metoprolol is used in:

• management of arterial hypertension;
• angina pectoris;
• cardiac arrhythmias;
• myocardial infarction;
• adjuvant treatment in hyperthyroidism;
• migraine prophylaxis.

Tablets - 5 mg

Nebiol contains the active substance nebivolol hydrochloride, which is a cardioselective beta-blocker (i.e. with a selective action on the cardiovascular system).

It exerts a dilating action on blood vessels, which contributes to lower blood pressure.

It also prevents increased heart rate and controls heart pumping strength.

Nebiol is indicated for the treatment of:

• essential hypertension (high blood pressure);

stable mild or moderate heart failure in addition to standard therapies in patients aged 70 years or over. 

Tablets - 20 mg

Nifedipine is a dihydropyridine calcium-channel blocker.

It inhibits the calcium ions flow through the cellular membrane. Nifedipine decreases the myocardial oxygen demand. It is a peripheral and coronary vasodilator, but, unlike the other calcium-channel blockers verapamil or diltiazem, has little or no effect on cardiac conduction and negative inotropic activity is rarely seen at therapeutic doses.

Nifedipine has no antiarrhythmic activity.

It widens the main coronary arteries and coronary arterioles, both in normal region but also in ischemic ones and is a strong inhibitor to their spasms. It lowers blood pressure at rest and at a certain level of stress. This is realized by widening peripheral arterioles and reducing total peripheral resistance.

Nifedipine 10 mg sugar-coated tablet is used in:

• angina;
• Raynaud's disease;

Nifedipine sugar-coated tablets can increase the risk of serious heart problems in patients with hypertension or angina. Hence, Nifedipine sugar-coated tablets are only used in these patients if no other treatments are appropriate.