Tablets - 25 mg
Hidroklortiazid, like all thiazide diuretics, increases urinary excretion of sodium and potassium in about equal amounts. As other effects can be mentioned: excretion of potassium and hydrogencarbonate ions, decrease of the excretion of calcium and uric acid retention. In maximum therapeutic doses, all thiazide diuretics are almost equal in concern of diuretic action. The exact mechanism of Hidroklortiazid is still not clear. The site of action of the drug is the peripheral renal tubule and ascendent part of the loop Henle. The drug inhibits the carboanhydrase enzyme thus affecting the transfer of hydrogencarbonates in the kidney. It does not exert any influence on normal arterial pressure. The antihypertensive effect in the initial stage is related to the reduction of extracellular fluid volume. Several days are needed for the antihypertensive effect. To achieve the optimal therapeutic effect are required 2 - 4 weeks.
Hidroklortiazid - tablets are used:
• to treat edema;
• in congestive heart failure, kidney disease, such as nephrotic syndrome;
• in liver cirrhosis;
• to treat hypertension, alone or in combination with other antihypertensive drugs.
