Solution for injection - (5%) 50 mg/ml
Vitamine B1 (thiamine hydrochloride) belongs to the group of water-soluble vitamins, although some of its derivatives have greater lipophilicity.
The main functions of thiamine hydrochloride are: carbohydrate metabolism, normal development of organism, neural impulse conductor and acetylcholine synthesis. Thiamine is essential for the normal aerobic metabolism. It combines with adenosine triphosphate (ATP) in the presence of thiamine diphosphokinase, to form thiamine pyrophosphate, an important coenzyme which is also known as cocarboxylase.
Thiamine pyrophosphate is the active form of thiamine which acts as a coenzyme in carbohydrate metabolism (in the decarboxylation of α – keto acids such as pyruvic acid and of α – ketoglutarate).
Thiamine deficiency appears when its intake with food is inadequate.
Severe deficiency causes beri-beri disease which is characterised by gastrointestinal disorders and peripheral neuropathy.
Vitamine B1 tablets and solution for injection are used in the following clinical situations:
• prophylaxis or treatment of thiamine deficiency (beri-beri)
• prophylaxis of Wernicke-Korsakoff syndrome
• treatment of ulcerative colitis, chronic diarrhea, cerebellar syndrome, polyneuritis and as appetite stimulant.
Administration of solution of injection is indicated when the oral administration is not possible or not recommended.
