Tablets - 500 mg

The place and mechanism of the analgesic effect of paracetamol are not completely elucidated. Paracetamol lowers temperature by directly acting in the center of thermoregulation in the hypothalamus; this center stimulates the process of temperature lowering through peripheral vasodilatation and through sweating. Paracetamol is as effective as aspirin in the inhibition of prostaglandin-synthetase in the central nervous system, but the peripheral inhibition of the synthesis of prostaglandins is minimal, which may be the cause for the absence of antirheumatic or anti-inflammatory effects that are with clinical importance. The analgesic and antipyretic effects of paracetamol are generally comparable with those of aspirin, but aspirin has a better effect than paracetamol against pain with an inflammatory origin.

Paracetamol does not inhibit the aggregation of thrombocytes and does not cause ulcers in the digestive tract.

Paracetamol is indicated as a suitable analgesic and antipyretic, especially in aspirin - sensitive patients, for patients with blood coagulation disorders or with stomach ulcer:

• in mild to moderate severe pain with different localizations (headache, toothache, neuralgia, myalgia, menstrual pain, post-traumatic and post-surgical pain);
• for temperature lowering in fever conditions.