Cardiovascular System

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ATC Reimbursed

List of reimbursed drugs, is an important part of Service Packages covering the Fund of Compulsory Health Care Insurances for the population. The list of reimbursable drugs aims at improving the quality of service for all patients, particularly for people in need. In this regard, through the new list of drugs, FCHC aims at increasing the attention toward categories such as retirees and patients suffering from serious illnesses.

In compiling the list of drugs there are some scientific criteria which have been taken into consideration, by giving priority to drugs used for severe diseases; diseases of high risk for life; diseases that cause disability; diseases that risk of being spread into the society; diseases that cause much suffering as well as chronic illnesses requiring prolonged treatment.

Cardiovascular System - Reimbursed

Tablets - 5 mg

Nebiol contains the active substance nebivolol hydrochloride, which is a cardioselective beta-blocker (i.e. with a selective action on the cardiovascular system).

It exerts a dilating action on blood vessels, which contributes to lower blood pressure.

It also prevents increased heart rate and controls heart pumping strength.

Nebiol is indicated for the treatment of:

  • essential hypertension (high blood pressure);

stable mild or moderate heart failure in addition to standard therapies in patients aged 70 years or over. 

Tablets - 20 mg

Nifedipine is a dihydropyridine calcium-channel blocker.

It inhibits the calcium ions flow through the cellular membrane. Nifedipine decreases the myocardial oxygen demand. It is a peripheral and coronary vasodilator, but, unlike the other calcium-channel blockers verapamil or diltiazem, has little or no effect on cardiac conduction and negative inotropic activity is rarely seen at therapeutic doses.

Nifedipine has no antiarrhythmic activity.

It widens the main coronary arteries and coronary arterioles, both in normal region but also in ischemic ones and is a strong inhibitor to their spasms. It lowers blood pressure at rest and at a certain level of stress. This is realized by widening peripheral arterioles and reducing total peripheral resistance.

Nifedipine 10 mg sugar-coated tablet is used in:

  • angina;
  • Raynaud's disease;

Nifedipine sugar-coated tablets can increase the risk of serious heart problems in patients with hypertension or angina. Hence, Nifedipine sugar-coated tablets are only used in these patients if no other treatments are appropriate.

Tablets - 10 mg

Nitrosorbit contains the active substance isosorbide dinitrate. The basic pharmacological effect of isosorbide dinitrate, as all organic nitrates, is relaxing vascular smooth muscles as a result of intracellular cyclic guanosine monophosphate production inducement. Arterioles relaxation reduces systemic vascular resistance and blood pressure.

Nitrosorbit 10 mg tablets are indicated in:

  • prophylaxis and treatment of angina pectoris;
  • left ventricular failure.

Tablets - 10 mg

Nitrosorbit contains the active substance isosorbide dinitrate. The basic pharmacological effect of isosorbide dinitrate, as all organic nitrates, is relaxing vascular smooth muscles as a result of intracellular cyclic guanosine monophosphate production inducement. Arterioles relaxation reduces systemic vascular resistance and blood pressure.

Nitrosorbit 10 mg tablets are indicated in:

  • prophylaxis and treatment of angina pectoris;
  • left ventricular failure.

Rectal cream - (0.1 mg + 20 mg)/g - 15 g

 

Tablets - 5 mg

 

Film coated tablets - 10 mg

 

Film coated tablets - 5 mg

 

Tablets - 40 mg

Propranolol contains the active substance propranolol hydrochloride, which is part of the beta - blockers group.

Propranolol 40 mg tablets are used:

  • in the management of hypertension;
  • in the treatment of angina pectoris;
  • in the prevention of other cardiac attacks, if you have passed one;
  • in the treatment of hypertrophic cardiomyopathy;
  • in the management of arrhythmias.

Propranolol tablets may also be used:

  • in the prevention of severe headache (migraine);
  • in the treatment of essential tremor;
  • in the management of anxiety and anxiety tachycardia;
  • as adjunctive treatment in the thyroid gland hyperactivity (thyrotoxicosis);
  • in the treatment of hypertension caused by the tumour in the adrenal gland – phaeochromocytoma (only with an alpha-blocker);
  • in the prevention of haemorrhage of the upper part of the gastrointestinal tract, in patients with hypertension in the liver and oesophageal varices.

Film coated tablets - 40 mg

Siprolip is a drug used to reduce high blood lipids (cholesterol) from the class of cholesterol synthesis enzyme inhibitor. The active substance of Siprolip, simvastatin, reduces cholesterol production in the liver. For simvastatin has been shown that in patients at high risk for coronary heart disease, it reduces the risk of suffering a heart attack or stroke.

Siprolip is used:

in addition of a diet in:

  • patients with hypercholesterolemia(primaryor mixed hyperlipidemia) when diet andother measures such asphysical training orweight lossalone are not sufficient;
  • patientswith homozygous familial hypercholesterolemia, along with other treatmentsorif suchare not suitable;
  • for the prevention of cardiovascular diseases:
  • in patients whosecholesterol levelsin the bloodarenormal or elevated,with establishedatherosclerotic cardiovasculardisease ordiabetes, along with other preventive measures.

 

Film coated tablets - 20 mg

Siprolip is a drug used to reduce high blood lipids (cholesterol) from the class of cholesterol synthesis enzyme inhibitor. The active substance of Siprolip, simvastatin, reduces cholesterol production in the liver. For simvastatin has been shown that in patients at high risk for coronary heart disease, it reduces the risk of suffering a heart attack or stroke.

Siprolip is used:

in addition of a diet in:

  • patients with hypercholesterolemia(primaryor mixed hyperlipidemia) when diet andother measures such asphysical training orweight lossalone are not sufficient;
  • patientswith homozygous familial hypercholesterolemia, along with other treatmentsorif suchare not suitable;
  • for the prevention of cardiovascular diseases:
  • in patients whosecholesterol levelsin the bloodarenormal or elevated,with establishedatherosclerotic cardiovasculardisease ordiabetes, along with other preventive measures.

Film coated tablets - 10 mg

Siprolip is a drug used to reduce high blood lipids (cholesterol) from the class of cholesterol synthesis enzyme inhibitor. The active substance of Siprolip, simvastatin, reduces cholesterol production in the liver. For simvastatin has been shown that in patients at high risk for coronary heart disease, it reduces the risk of suffering a heart attack or stroke.

Siprolip is used:

in addition of a diet in:

  • patients with hypercholesterolemia(primaryor mixed hyperlipidemia) when diet andother measures such asphysical training orweight lossalone are not sufficient;
  • patientswith homozygous familial hypercholesterolemia, along with other treatmentsorif suchare not suitable;
  • for the prevention of cardiovascular diseases:
  • in patients whosecholesterol levelsin the bloodarenormal or elevated,with establishedatherosclerotic cardiovasculardisease ordiabetes, along with other preventive measures.

 

Tablets - 25 mg

Spirolan contains spironolactone as an active substance which is a diuretic drug (potassium - sparing).

Spirolan is used in:

  • primary hyperaldosteronism (excessive production of a mineralocorticoid, aldosterone), if surgery is not indicated;
  • accumulation of fluid in tissues and / or abdomen (oedema and / or ascites) in diseases associated with secondary hyperaldosteronism.

 

Tablets - 50 mg

Spirolan contains spironolactone as an active substance which is a diuretic drug (potassium - sparing).

Spirolan is used in:

  • primary hyperaldosteronism (excessive production of a mineralocorticoid, aldosterone), if surgery is not indicated;
  • accumulation of fluid in tissues and / or abdomen (oedema and / or ascites) in diseases associated with secondary hyperaldosteronism.

 

Tablets - 50 mg + 25 mg

Triam H is a medicine which promotes water excretion and it is used for its antihypertensive effects.

The active substances of Triam H are triamterene and hydrochlorothiazide.

This medicine is used:

  • in high blood pressure (arterial hypertension);
  • in cases of abnormal water retention (oedemas) due to cardiac, liver or renal disorders;
  • in chronic heart failure.

Film coated tablets - 300 mg

 

Film coated tablets - 150 mg

 

Film – coated tablets - 160 mg

Film-coated tablets - 80 mg

Film coated tablets - 80 mg

Veprol contains the active substance verapamil hydrochloride.

Verapamil is a calcium channel blocker. The mechanism of action consists in inhibiting the entrance of calcium into the cell. Verapamil acts in smooth muscle, myocardial cells, and cells within the sino-atrial and atrioventricular nodes. The main actions of the calcium-channel blockers include dilation of coronary and peripheral arteries and arterioles. Verapamil causes slowing of atrioventricular conduction, reduction of heart rate and a negative inotropic action.

Verapamil is used in the treatment of:

  • supraventricular arrhythmias;
  • angina pectoris;
  • hypertension. 
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