Solution for injection - 50 mg / 2 ml

Promethazine is a phenothiazine derivative, which decreases or eliminates the main histamine actions by competing with histamine or reversibly blocking histamine receptors in tissues. Promethazine does not deactivate histamine, and does not prevent its secretion. H₁ receptors are responsible for blood vessel dilation, increase of capillary permeability, itching and, up to an extent, for bronchial and gastrointestinal tract smooth muscle contractions. Promethazine has also antimuscarinic properties, antagonizing effects of adrenaline and serotonin and local anesthetic effects.

Prometazine 50 mg / 2 ml solution for injection is indicated:

By intramuscular injection:

• in allergy;
• in preoperative sedation;
• in sedation during labor;

By intravenous injection:

• in allergy

as an adjuvant agent in anaesthesia and analgesia in order to reduce the dose of pethidine or other narcotic analgesics, especially in several specific surgical procedures (for example: repeated bronchoscopy, surgical ophthalmologic intervention).