List of reimbursed drugs, is an important part of Service Packages covering the Fund of Compulsory Health Care Insurances for the population. The list of reimbursable drugs aims at improving the quality of service for all patients, particularly for people in need. In this regard, through the new list of drugs, FCHC aims at increasing the attention toward categories such as retirees and patients suffering from serious illnesses.
In compiling the list of drugs there are some scientific criteria which have been taken into consideration, by giving priority to drugs used for severe diseases; diseases of high risk for life; diseases that cause disability; diseases that risk of being spread into the society; diseases that cause much suffering as well as chronic illnesses requiring prolonged treatment.
Nervous System - Reimbursed
Solution for injection - (2.5%) 50 mg/2 ml
Sugar coated tablets - 25 mg
Levomepromazine belongs to the group of phenothiazine neuroleptics.
It acts on hypothalamus, thalamus, reticular formation and on lymbic system, inhibiting the sensory impulses.
Levomepromazine antagonizes dopamine D2 receptors, 5HT3-serotonin receptors, histamine H1 receptors, and cholinergic (muscarinic) receptors.
As a result of this antagonism appears a calming effect in small doses, an antipsychotic effect in high doses, as well as increase of the threshold of pain and stimulation of amnesia.
Levomepromazine also has analgesic, antihistaminic and anticholinergic effect.
This medicine does not cause respiratory depression, therefore it is useful especially in patients with low respiratory reserve.
Levomepromazine is used in the treatment of:
Sugar coated tablets - 10 mg
Librian contains the active substance chlordiazepoxide, which like all other benzodiazepines, potentiates the effects of the gamma-aminobutiric acid (GABA) (facilitates the inhibitory neurotransmition of GABA) and of the other inhibitory neurotransmitters, by binding with the specific benzodiazepinic receptors. The potentiation of the effects of GABA causes the inhibition of the central nervous system.
Librian is almost completely absorbed after oral administration. It is highly bound (about 96%) to plasmatic proteins, while its elimination half-life is from 5 to 30 hours. Chlordiazepoxide passes in the cerebrospinal fluid and in breast milk, as also in the placenta. Metabolites pharmacologically active of chlordiazepoxide are: desmethylchlordiazepoxide, demoxepam, desmethyldiazepam and oxazepam. The unchanged drug and the metabolites are excreted through urine, mainly as coniugated metabolites.
Librian sugar-coated tablets are used in the:
Tablets - 60 mg
Tablets - 15 mg
Luminal contains as active substance phenobarbital, which is part of the group of barbiturates. It may affect the brain activity at different levels, from excitation to mild sedation to hypnosis and coma. High therapeutic doses of barbiturates may produce anesthesia. Overdoses may cause death. Phenobarbital depresses the sensory cortex, decreases motor activity, alters cerebellar function and causes drowsiness, sedation and hypnosis. Barbiturates have poor analgesic activity in subanesthetic doses and may increase the response to painful stimuli. All barbiturates exhibit anticonvulsant action at anesthetic doses. Barbiturates are respiratory depressants. The degree of respiratory depression is dependent upon the dose. Barbiturates are absorbed in varying degrees following oral or parenteral administration. The salts are absorbed faster than the acids. The rate of absorption is increased if sodium salts are given as a dilute solution or taken on an empty stomach. The onset of action ranges from 20 to 60 minutes after oral administration. After intramuscular injection, the onset of action is more rapid, while after intravenous administration the action may start after 5 minutes. Maximal depression of central nervous system may not occur until 15 minutes after intravenous injection.
Luminal is used:
Solution for injection - (1%) 10 mg/ml
Film-coated tablets - 10 mg
Tablets - 5 mg
Parkinsan contains the active substance trihexyphenidyl hydrochloride.
It is an antimuscarinic agent with similar effects as atropine.
It exerts direct inhibitory effect on the parasimpatique nervous system by inhibiting the effects of acetylcholine.
Parkinsan has also an antispasmodic effect on the smooth muscles.
Parkinsan 5 mg tablets are indicated:
Solution for injection - (5%) 100 mg/2 ml
Tabletes - 50 mg
Tablets - 200 mg
Film coated tablets - 2 mg
Risocon contains risperidone as active substance. Risocon belongs to a group of medicines called ‘anti-psychotics’.
Risocon is used:
Oral solution - 1 mg / ml
Film-coated tablets - 25 mg
Capsules - 50 mg