Tablets - 10 mg

Amlodipine is a calcium-channel blocker of the dihydropyridine group and prevents transmembrane displacement of the calcium ions in cardiac smooth muscles and those of the blood vessels. The antihypertensive action is due to the relaxing effect on the smooth muscles of arteries.

The exact mechanism by which amlodipine relieves angina has not been finally determined but amlodipine reduces the total ischemic burden due to the following actions:

1) amlodipine dilates peripheral arterioles and thus reduces the total peripheral resistance against which the heart works; since the heart speed remains constant, the heart load reduction reduces energy consumption and myocardial oxygen requirements;

2) the mechanism of action of amlodipine also may include enlargement of the main coronary arteries and coronary arterioles, either in normal and also ischemic regions; the enlargement increases myocardial oxygen supply in patients with coronary artery spasm (Prinzmetal angina).

Indications:

• Hypertension, it may be used alone or in combination with other antihypertensive agents.
• Ischemic heart disease (chronic stable angina), it may be used alone or in combination with other antianginal agents.

Vasospastic angina (Prinzmetal’s angina), as monotherapy or with other antianginal drugs.