Tablets - 25 mg

Solution for injection - (0.1%) 1 mg/1 ml

Tablets - 5 mg

Solution for injection - (10%) 1 g/10 ml

Tablets - 500 mg

Metformine is an oral antidiabetic which is not chemically or pharmacologically related to sulfonylurea derivatives. Metformine improves glucose tolerance in non-insulin-dependent diabetes mellitus by reducing basal and after-meal blood glucose levels. Metformine also reduces hepatic glucose production, intestinal glucose absorption and improves insulin sensitivity (increases peripheral glucose uptake).

Metformine is indicated in non-insulin-dependent diabetes mellitus when treatment by diet modification alone has not been effective and when the patient is overweight. Metformine may be used alone as initial treatment or in combination with a sulfonylurea derivative.

In insulin-dependent diabetes mellitus, Metformine may be used as adjunctive treatment in patients whose symptoms are difficult to manage.