Sugar coated tablets - 25 mg

Promethazine is a phenothiazine derivative, which decreases or eliminates the main histamine actions by competing with histamine or reversibly blocking histamine receptors in tissues. Promethazine does not deactivate histamine, and does not prevent its secretion. H₁ receptors are responsible for blood vessel dilation, increase of capillary permeability, itching and, up to an extent, for bronchial and gastrointestinal tract smooth muscle contractions. Promethazine has also antimuscarinic properties, antagonizing effects of adrenaline and serotonin and local anesthetic effects.

Prometazine 25 mg sugar-coated tablets are indicated in:

• temporary relief of rhinorrhea and sneezing associated with flu;
• symptomatic relief of seasonal and perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis;
• relief of symptoms such as pruritus of allergic and non-allergic origin;
• treatment of mild, uncomplicated skin manifestations of urticaria and angioedema;
• alleviation of allergic reactions from blood or plasma transfusions;
• treatment of dermographism;
• ancillary treatment in anaphylactic reactions;
• preoperative and postoperative sedation;
• prevention and management of nausea and vomiting associated with certain types of anaesthesia and surgical procedures;
• adjuvant treatment to analgesics for control of postoperative pain;
• facilitation of sleep;
• prevention and treatment of motion sickness (travelling by automobile, plane, ship).