Suppositories – 75 mg

Suppositories – 150 mg

Tablets - 70 mg

Tablets - 300mg

Alopurin is a medicine which inhibits the formation of uric acid (uricostatic).

Alopurin is indicated:

Adults

• in cases where blood uric acid values are 500 µmol/l (8.5mg/100 ml) and above, provided it is dietary unmanageable, or in clinical complications with hyperuricemic conditions, especially manifested gout, renal damage caused by uric acid (uratenephropathy),treatment and prevention of uric acid stones, and to prevent the formation of calcium oxalate stones in concomitant hyperuricemia;
• in raised blood uric acid levels and increased excretion of uric acid in urine, e.g. in strong cell decay, radiation or chemotherapy (secondary hyperuricemia).

Gel - 1%

Durilac contains the active substance diclofenac sodium, which is a non-steroidal anti-inflammatory drug (NSAID). Its action is based in the inhibition of cyclooxygenases, which participate in the biosynthesis of prostaglandins. Prostaglandins have an important role in the process of pain, inflammation and chills. Non - steroidal anti-inflammatory drugs inhibit cyclooxygenases-1 and-2 (COX-1 and-2). Inhibition of COX-1 is associated with gastrointestinal side effects, while the inhibition of COX-2 is associated with anti-inflammatory action.

Diclofenac is rapidly absorbed when it is given in the form of rectal suppositories or intramuscular injection. Diclofenac is also absorbed percutaneously. Approximately 99 % of the drug is bound with the plasma proteins. Diclofenac passes in the synovial fluid and in the breast milk. Its plasmatic half life is 1 – 2 hours. It is excreted in the form of glucuronides and sulphates, mainly through urine (65 %) and bile (35 %).

Durilac is used:

• in musculo-skeletal disorders such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis;
• in peri-articular disorders such as bursitis and tendinitis;
• in soft-tissue disorders such as sprains and strains;
• in painful conditions such as renal colic, acute gout, dysmenorrhoea;
• after some surgical procedures.