Tablets - 0.25 mg

Digoxin is a digitalic cardiac glycoside used in the treatment of supraventricular arrhythmia, and especially in atrial fibrillation and heart failure. Its main action is to increase the contractility of the heart muscle and also slowing down the heart conduction, especially through atrioventricular node. Digoxin exerts a direct action on smooth muscles of blood vessels and a non-direct action starting from autonomic nervous system and especially by increased vagal activity.

Alterations of autonomic activity reflexes that depend from effects on circulatory system are also observed. Especially these effects result in positive inotropic effect, negative chronotropic effect and in slowing down the activity of atrioventricular node. In conclusion, the beneficial effects of digoxin are a result of direct actions on heart muscle, as well as of the indirect action on the cardiovascular system due to the effects on the autonomic nervous system.