lightbox[Dengueenglish]Paracetamol and Ibuprofen!

 

Paracetamol and Iboprufen are two qualitative medications that help reduce the temperature and relieve pain in children. 

In drug stores these medications are found as syrup form or suppository.

Paracetamol syrup 120 mg / 5 ml; 

Paracetamol suppository - 100mg, 125mg, 250mg. 

Fasdol (ibuprofen) - syrup 100mg / 5ml 

Fasdol suppository - 75mg, 150mg. 

Both these drugs are antipyretics and analgesics, but unlike Paracetamol, Fasdol (ibuprofen) is also anti-inflammatory.

The absence of anti-inflammatory activity of paracetamol to the fact that Paracetamol is an inhibitory (inhibitory) weak cyclooxygenase. This drug also inhibits the activity of neutrophils not unlike ibuprofen. Antipyretic activity is due to inhibition of ciclogenesis - 3 (COX-3). Rapidly absorbed in the gastrointestinal tract (95-98%); rapidly distributed and metabolized in the organic fluid in liver. A very small fraction eliminated in urine (2-3%). 

Iboprufen through inhibition of the enzyme cyclooxygenase - 1 (COX-1) and Cyclooxygenase - (COX-2), leads to reduced synthesis of prostaglandins, the most important mediators of inflammation, pain and hyperpiesia (high temperature). Compared with paracetamol, Fasdol has a greater duration of action in the body. This is why making less, every 6 to 8 hours no more than 3 times a day.

Ibuprofen not being selective enzymes (COX -1, -2 COX) has the side effect of stomach irritation, so always consult his taking after meals. Paracetamol is easy as taking his medication but for a long time and in large doses impairs the liver. It is recommended receiving doses prescribed by a doctor or pharmacist, drinking every 4 to 6 hours and not more than 5 times in a 24 hour period. If the child at the same time taking another medication to avoid a potentially fatal overdose should ensure that other drug does not contain paracetamol. At high temperatures above 38.5 ° C it is recommended to take Fasdol (syrup or suppository), while at lower temperatures it is advisable always taking paracetamol as directed by your doctor or pharmacist.