Solution for injection - (202 mg + 50.5 mg) / 10 ml (2.5%)

Solution for infusion - 0.5% - (5 g/1000 ml)

Metronidazole, a synthetic derivative of nitroimidazole, acts against gram-positive and gram-negative anaerobic microorganisms (Bacteroides species, including the B.fragilis bacterial group, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species and against protozoan (Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia). The mechanism of action of metronidazole is not yet clear. It is thought that metronidazole inhibits the synthesis of DNA. It has bactericidal action.

Metronidazol is used in:

• the treatment of infections caused by anaerobic microorganisms and infections from protozoa;
• prevention of postoperative infections caused by anaerobic bacteria, especially bacteroides and anaerobic streptococci species;
• the treatment of septicemia, bacteremia, peritonitis, brain abscess, necrotizing pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis and postoperative infections wounds when from them are isolated sensitive anaerobic pathogen microorganisms; urogenital trichomoniasis in females (trichomonial vaginitis) and in males; bacterial vaginosis (also known as non-specific vaginitis), or anaerobic vaginosis or Gardnerella vaginitis;
• acute ulcerative gingivitis; leg ulcers, infected by anaerobic microorganisms;
• acute dental infections (e.g. acute pericoronitis and acute apical infections);
• all forms of amoebiasis (intestinal and extraintestinal disease) and those of asymptomatic cyst holders;
• giardiasis;
• treatment of Helicobacter pylori, in combination with other medicines.

Syrup - 2 mg/5 ml - 150 ml

Solution for infusion - 5 g/1000 ml - 100 ml

Metronidazole, a synthetic derivative of nitroimidazole, acts against gram-positive and gram-negative anaerobic microorganisms (Bacteroides species, including the B.fragilis bacterial group, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species and against protozoan (Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia). The mechanism of action of metronidazole is not yet clear. It is thought that metronidazole inhibits the synthesis of DNA. It has bactericidal action.

Metronidazol is used in:

• the treatment of infections caused by anaerobic microorganisms and infections from protozoa;
• prevention of postoperative infections caused by anaerobic bacteria, especially bacteroides and anaerobic streptococci species;
• the treatment of septicemia, bacteremia, peritonitis, brain abscess, necrotizing pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis and postoperative infections wounds when from them are isolated sensitive anaerobic pathogen microorganisms; urogenital trichomoniasis in females (trichomonial vaginitis) and in males; bacterial vaginosis (also known as non-specific vaginitis), or anaerobic vaginosis or Gardnerella vaginitis;
• acute ulcerative gingivitis; leg ulcers, infected by anaerobic microorganisms;
• acute dental infections (e.g. acute pericoronitis and acute apical infections);
• all forms of amoebiasis (intestinal and extraintestinal disease) and those of asymptomatic cyst holders;
• giardiasis;
• treatment of Helicobacter pylori, in combination with other medicines.

Oral suspension - 125 mg/5 ml - 120 ml

Mezyl contains the active ingredient metronidazole. Metronidazole, a synthetic derivative of nitroimidazole, is active against several anaerobic gram-positive and gram-negative microorganisms (Bacteroides fragilis and other Bacteroides spp., Clostridium spp., Eubacterium spp., Peptococcus spp., and Peptostreptococcus spp.) and several protozoa (Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia). The mechanism of action of metronidazole is not entirely clear, but it is thought to inhibit DNA synthesis. Metronidazole has a bactericidal action.

It is indicated in:

• treatment of infections caused by anaerobic microorganisms, and protozoan infections;
• the prevention of post-operative infections due to anaerobic bacteria, particularly species of Bacteroides and anaerobic Streptococci;
• treatment of septicaemia, bacteraemia, peritonitis, brain abscesses, necrotizing pneumonia, osteomyelitis, puerperal sepsis, pelvic abscesses, pelvic cellulitis and post-operative wound infections from which pathogenic anaerobes have been isolated, urogenital trichomoniasis in females (trichomonal vaginitis) and in males; bacterial vaginosis (known as nonspecific vaginitis), anaerobic vaginosis or Gardnerella vaginitis;
• acute ulcerative gingivitis; anaerobically-infected leg ulcers or pressure sores;
• acute dental infections (e.g. acute pericoronitis and acute apical infections);
• all forms of amoebiasis (intestinal and extra-intestinal disease) and symptomless cyst passers;
• giardiasis;
• eradication of Helicobacter pylori, in combination with other drugs.

Film-coated tablets - 500 mg

Tablets - 100 mg

Nitrofurantoin is an antibacterial, which belongs to the group of nitrofuranes.

The mechanism of action of nitrofurantoin has not yet been clarified. There is evidence that this substance inhibits a range of enzymatic systems of bacteria and confirmed that it interferes in the early stages of bacterial carbohydrate metabolism, by inhibiting acetyl coenzime A. Nitrofurantoin acts against a broad spectrum of common pathogen microbes of urinary tract. Most strains of Escherichia coli are sensitive; also, most of strains of Klebsiella - Enterobacter are sensitive to nitrofurantoin.

Nitrofurantoine is indicated in prophylaxis and treatment of acute or recurrent, uncomplicated lower urinary tract infections, either spontaneous or following surgical procedures.

Nitrofurantoine is specifically indicated for the treatment of infections when due to susceptible strains of Escherichia coli, Enterococci, Staphylococci, Citrobacter, Klebsiella and Enterobacter. Most strains of Proteus and Serratia are resistant. All Pseudomonas strains are resistant.

Tablets - 250 mg

Tablets - 750 000 UI

Spiramicine is a macrolide antibiotic that has similar uses with erythromycin. Macrolides are weak bases; their activity increases at alkaline pH. Macrolides penetrate into the pleural fluid, in the ascitic fluid, in the middle ear exudates and in the sputum. When the meninges are inflamed, they can enter in the cerebrospinal fluid. Macrolides are used in respiratory tract, urogenital, digestive and skin soft tissue infections, especially when beta-lactamic antibiotics or tetracyclines are contraindicated.

Spiramicine is indicated in:

• the treatment of otorhinolaryngological, bronchopulmonary, stomathological, genital (especially of prostate origin), bone and skin infections;
• the prophylaxis of meningitis by meningococcus;
• the cases when rifampicin is contraindicated;
• the toxoplasmosis of old women.

Suspension – 40 %

Tablets - 400 mg + 80 mg

Emulsion - 25% - 200 ml

Tablets - 250 mg

Piperazine is an antihelmintic that acts against roundworms (Ascaris lumbricoides) and pinworms (Enterobius vermicularis). In roundworms, piperazine causes neuromuscular block leading to muscle paralysis of these parasites, which then are easily dislodged from their position by the movement of the gut and expelled in the faeces.

Piperazine 250 mg tablets are indicated in the treatment of ascaridiasis and enterobiasis.

Tablets – 100 mg

Alopurin is a medicine which inhibits the formation of uric acid (uricostatic).

Alopurin is indicated:

Adults

• in cases where blood uric acid values are 500 µmol/l (8.5mg/100 ml) and above, provided it is dietary unmanageable, or in clinical complications with hyperuricemic conditions, especially manifested gout, renal damage caused by uric acid (urate nephropathy),treatment and prevention of uric acid stones, and to prevent the formation of calcium oxalate stones in concomitant hyperuricemia;
• in raised blood uric acid levels and increased excretion of uric acid in urine, e.g. in strong cell decay, radiation or chemotherapy (secondary hyperuricemia).

Film-coated tablets - 25 mg

Oral solution - 1 mg / ml

Solution for injection - 0.5 mg / 1 ml

Suppositories – 75 mg

Suppositories - 100 mg

Indomethacin belongs to the group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). These drugs are soothing pain medications and reduce swelling (inflammation) with all its signs.

Indometacine suppositories can be used for:

•  inflammatory diseases of the joints or surrounding tissues such as rheumatoid arthritis,  osteoarthritis and degenerative diseases of the coxo-femoral joint;
•   deformation and stiffness of spinal cord (ankylosing spondylitis);
•   muscle pain, back pain and pain coming from the bones;
•   menstrual pain;
•   gout.

Tablets - 70 mg